The building in which Belgrave Veterinary Clinic resides was built in 1925.  It was originally council-owned, home to the experimental and progressive school of its time: Belgrave Grammar. In 1938, the building is thought to have been moved closer to the road and rotated 90 degrees to become a Baby Health Centre. In 1947, the building received its brick facade extension which now acts as the clinic waiting room. From 1952, it has been home to an antenatal clinic, and more recently the Dandenong Ranges Emergency Relief Service (now relocated to the Belgrave Hub a few steps down the road).

In 2018, the building changed hands and has since been renovated by Belgrave Veterinary Clinic.